Preparation Of Protein-Steroid Conjugates And Antisera Against 0Estradi0L-17β
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Preparation of agglutinating antisera and fluorescent-antibody conjugates against Pasteurella tularensis in equines.
The serological response in burros and horses to the viable LVS strain of Pasteurella tularensis was studied. High-titered agglutinating antisera and fluorescent-antibody conjugates were obtained in both groups of animals. Maximum titers were obtained in horses 14 to 21 days after the start of vaccination and in burros 21 to 28 days after the start of vaccination. The use of Woodhour's adjuvant...
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Conjugates of bovine serum albumin with progesterone, deoxycorticosterone, and estrone have now been synthesized as an extension of a program to prepare and characterize steroid-protein conjugates with the ultimate purpose of testing their ability to stimulate the formation of antihormonal antibodies (1). The steroid derivatives which were coupled to albumin are shown in Fig. 1. The synthetic a...
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Alkaline treatment of Pseudomonas aeruginosa type 5 lipopolysaccharide (LPS) resulted in reduced toxicity as measured by both the Limulus amoebocyte assay and the rabbit pyrogenicity test. Chemical analysis of the deacylated LPS (D-LPS) revealed that ester-linked fatty acids were removed while the amide-linked fatty acids remained intact. The neutral and amino sugar compositions for native LPS ...
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Enzymes, fluorochromes and other marker molecules are commonly used in a variety of applications to provide specific detection signals. To this aim, they may be conjugated to antibodies, avidin, protein A or G and other proteins in many ways. Fundamental work on chemical modification of proteins and antibody labelings has already been done long before AH COONS and co-workers employed those tech...
متن کاملMacromolecular prodrugs. XIII. Hydrosoluble conjugates of 17β-estradiol and estradiol-17β-valerate with polyaspartamide polymer.
Two hydrosoluble conjugates of 17β-estradiol (ED) and estradiol-17β-valerate (EV) with polyaspartamide polymer were prepared and characterized. ED and EV were first chemically modified and bound to poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-aminoethyl-DL-aspartamide)] (PAHA), a hydrosoluble polyaspartamide-type copolymer bearing both hydroxyl and amino groups. ED was first conver...
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ژورنال
عنوان ژورنال: Acta Veterinaria Scandinavica
سال: 1973
ISSN: 1751-0147
DOI: 10.1186/bf03547446